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International Meeting on Dermatopathology & Skin Care

Paris, France

Warkaa Mahmood Ali Al-Wattar

Warkaa Mahmood Ali Al-Wattar

Mustansiriyia University, Iraq

Title: Effect of 790-805 nm diode laser therapy on mast cell in cutaneous wound healing in mice


Biography: Warkaa Mahmood Ali Al-Wattar


Background & Objective: The use of low level laser therapy (LLLT) has been increased now-a-days to accelerate healing of soft tissue injuries because of some biostimulatory effects. The goal of this study was to investigate the effect of 790-805 nm diode lasers on the inflammatory effect of mast cells during wound healing in rodents.

Materials & Methods: A cut wound (1.5 cm) was done on the cheek of 40 albino mice. Twenty of them exposed to LLLT (360 J/cm2) at 790-805 nm immediately post wounding procedure. The animals were scarified and the wound area was prepared and stained with toluidine blue.

Results: Mean mast cell count of 10.2 on the first day of control group while in laser group 8.4. The control and laser group showed a gradual inclination in the mean value to be return to increase at the day 14 of the experiment. There was a significant difference (P<0.05) in the control group on the first day, while significant difference (P≤0.05) was on the day seven. Pearson correlation showed a significant correlation (P≤0.01) between the control group on the day one and the laser group on the day seven. While there was a significant correlation (P≤0.05) between the control group on the day 14 and laser group on the day one.

Conclusions: LLLT may induce an anti-inflammatory effect on wound healing process by its inhibitory action on mast cells; while it may have a biostimulatory effect on the proliferation of mast cells in the proliferative phase of wound healing which indirectly affects fibrous tissue regeneration in the subcutaneous area.