Biography:

Huang Wei Ling, born in Taiwan, raised and graduated in medicine in Brazil, specialist in infectious and parasitic diseases, a General Practitioner and Parenteral and Enteral Medical Nutrition Therapist. Once in charge of the Hospital Infection Control Service of the City of Franca’s General Hospital, she was responsible for the control of all prescribed antimicrobial medication and received an award for the best paper presented at the Brazilian Hospital Infection Control Congress in 1998. Since 1997, she has been presenting her work worldwide, working with the approach and treatment of all diseases of all systems of the human body in a holistic way, with treatment guided through the teachings of Traditional Chinese Medicine and Hippocrates.
 

Abstract:

Introduction: Urticaria are red, itchy welts that result from a skin reaction. The cause of chronic urticaria is not clear in Western Medicine. According to the author, the reactions are consequences of deficiency of Blood, Yin, Yang, Qi  energies, formation of Heat retention, and lack of the energy of the chakras centers.

Purpose: To demonstrate that one of the possible causes of the urticaria’s problem is in the root or energy level and the treatment of these imbalances could lead to cure of the pathology.

Methods: Two case reports. An eight-year-old girl, who had Urticaria after consumption of pork meat, presenting swollen eyes, month and lips, hashes would appear on her skin and once even glottis edema. The second case, 30-year-old female, who presents hives for emotional reasons. Both patients treatment consisted in: 1.Chinese dietary counselling, 2.auricular acupuncture with apex ear bloodletting, 3.Chakras measurement, which appeared depleted (level 1 of 8). They were treated with crystal-based medications and homeopathy. 

Results: The first patient presented complete improvement of the crisis, and nowadays she can consume meat pork without allergic reactions. The second patient had diminution of the crisis in the first 30 days of treatment.

Conclusion: In the two case reports described, the depletion of the energy of the chakras was a common factor and the treatment to replenish these energies is important for achieving success in treating the Urticaria symptoms without requiring the use of anti-histamines and corticosteroids that could induce more energy imbalances maintaining the symptoms.

Biography:

Oleg Gerasimenko has completed his PhD in 1991 from Bogomoletz Institute of Physiology and postdoctoral studies from The University of Liverpool, UK. He is a Reader at Cardiff School of Biosciences, Cardiff University, UK and Fellow of The Physiological Society UK. He has published 90 papers in reputed journals and has been serving as an Editorial board member of Scientific Reports and Pflugers Archiv.

.

Abstract:

Asparaginase-based drugs are very successful against childhood acute lymphoblastic leukaemia (ALL), however, they can induce Acute pancreatitis (AP) as a side effect and force clinicians to discontinue the treatments. AP is a frequent human disease with a substantial mortality with no specific therapy. Previous investigations into the mechanisms of AP established that intracellular ATP loss is a crucial factor leading to calcium overload and necrosis. We have recently reported that glucose metabolism is severely inhibited under AP conditions due to inhibition of hexokinases. ATP loss and calcium exacerbate each other and lead to necrosis. We have found that, replacing or supplementing glucose with galactose has markedly reduced the loss of ATP, calcium overload and subsequent necrosis in vitro. Galactose as an oral supplement has effectively protected against AP in two different mouse models of AP. In both cases, galactose has markedly reduced pancreatic histology scores, acinar necrosis and inflammation. We suggest that galactose oral supplement may be used to protect against AP and therefore improve efficacy of the childhood ALL treatments.

Biography:

Abstract:

Asparaginase-based drugs are very successful against childhood acute lymphoblastic leukaemia (ALL), however, they can induce Acute pancreatitis (AP) as a side effect and force clinicians to discontinue the treatments. AP is a frequent human disease with a substantial mortality with no specific therapy. Previous investigations into the mechanisms of AP established that intracellular ATP loss is a crucial factor leading to calcium overload and necrosis. We have recently reported that glucose metabolism is severely inhibited under AP conditions due to inhibition of hexokinases. ATP loss and calcium exacerbate each other and lead to necrosis. We have found that, replacing or supplementing glucose with galactose has markedly reduced the loss of ATP, calcium overload and subsequent necrosis in vitro. Galactose as an oral supplement has effectively protected against AP in two different mouse models of AP. In both cases, galactose has markedly reduced pancreatic histology scores, acinar necrosis and inflammation. We suggest that galactose oral supplement may be used to protect against AP and therefore improve efficacy of the childhood ALL treatments.

Biography:

Junghwa Yang, MD, is a resident of the Kangbuk samsung hospital. Born in 1991 in Busan, South Korea, he graduated with honors in medicine at the Seoul National University. She is now going on resident in the department of dermatology.

Abstract:

Primary cutaneous cribriform carcinoma (PCCC) is a rare and under-recognized sweat gland tumor that primarily presents as a subcutaneous nodule on the extremities of middle-aged individuals. The main histopathological features are anastomosing tubules and solid nests producing a sieve-like appearance. PCCC is regarded as an apocrine tumor based on the observation of decapitation secretion in the neoplastic cells.

A 57-year-old female presented with an asymptomatic firm nodule on the back. The lesion gradually increased in size and hardened. Histopathologic examination revealed unencapsulated, circumscribed dermal nodules composed of atypical epithelial cells in a cribriform-like pattern. There were occasional atypical mitotic figures and nuclear pleomorphism of the cells within the cribriform ducts and solid nests. In the immunohistochemical analysis, stromal cells were weakly positive on SMA stain, but there was no evidence of a myoepithelial layer on either hemotoxylin and eosin-stained sections or by immunohistochemistry with p63 and SMA. The possibility of cribriform-patterned metastasis from primary visceral carcinoma was excluded by the breast ultrasonography, abdominal ultrasonography, endoscopic exams, and whole-body fusion PET-CT. Wide excision was performed for the treatment and the postoperative site has been stable without any recurrence. 

Herein, we introduce this as a rare case of PCCC on the back.

Biography:

Dr. Phuong Thi Thanh Nguyen is a passionate young dermatologist who has been working as doctor and lecturer at Hue Medical University Hospital and Hue University of Medicine and Pharmacy which is one of the three main Medical University in Vietnam. She got Wyss scholarship for a Dermatopathology course at Columbia University in the city of New York under the supervision of Dr. David Silvers in 2015. Since then, she joined the weekly video conference with the dermatologists and pathologists from USA and various regions in Vietnam to consult cases based on clinical and histopathological features. She dreams of acquiring a level of competency in dermatopathology  to contribute in developing a high quality dermatologic educational training program in Hue to well educate the students and physicians, and of course, most important, to care for our patients.

Abstract:

Red skin syndrome or topical corticosteroid (TCS) withdrawal is a potential complication of TCS treatment, which especially occurs after a long-term use of moderate-to-potent TCS on the face or genital area. The objective of this clinical case report is to highlight understanding about clinical features and proposed treatment ofthis unusual skin disorder due to the abuse of TCS which has been a remarkable problem in Vietnam.

We describe a case of a 57-year-old woman who presentedto our dermatology clinic with a severe itchy, burning, stinging and swelling face after abrupt discontinuation of TCS. She reported one-year history of uncontrolled application ofskin whitening cream containing corticosteroids on her face. Examination found confluent scaly erythematous edematous plaques, skin atrophy and telangiectasia all over her face. She has been treated with a slow tapering of low-potency topical steroids combined facial care with the use of organic oil containing coconut, walnut oil, vitamin E and moisturiser, microneedling with PRP and dye pulsed light on the affected area. After two months, her skin condition was improved significantly.

In conclusion, red skin syndrome has been receiving a great deal of public attention. By raising awareness about its clinical features and risk factors, patients and providers could identify and prevent this complication. The treatment depends on personal clinical characteristics of each patient.

Biography:

SHINTARO ASAI has a passion for plastic surgery and aesthetic surgery, graduated Nagoya University school of Medicine in 1990.He has experienced in research, evaluation, teaching and administration both in hospital and education institutions for many years, especially interested in the research of aponeurotic blepharoptosis.Now, His institute is NAGOYA KYORITSU HOSPITAL, NAGOYA JAPAN

Abstract:

Biography:

Huang Wei Ling, born in Taiwan, raised and graduated in medicine in Brazil, specialist in infectious and parasitic diseases, a General Practitioner and Parenteral and Enteral Medical Nutrition Therapist. Once in charge of the Hospital Infection Control Service of the City of Franca’s General Hospital, she was responsible for the control of all prescribed antimicrobial medication and received an award for the best paper presented at the Brazilian Hospital Infection Control Congress in 1998. Since 1997, she has been presenting her work worldwide, working with the approach and treatment of all diseases of all systems of the human body in a holistic way, with treatment guided through the teachings of Traditional Chinese Medicine and Hippocrates.
 

Abstract:

Introduction: Scleroderma is a rare disease that hard and tight the skin and its connective tissues.  Traditional Chinese Medicine (TCM) associates the disease with a Qi and Yang deficiency and coldness leading to blood statis.

The purpose of this study is to demonstrate that energ alterations have an influence on the formation of scleroderma and to propose an effective treatment using ancient medical tools, associated with Western standard treatment.

Methods: A case report of a female patient, 58 years old, diagnosed with scleroderma and in chronic use of corticosteroids. The patient presented a stiffening of the skin, with slim stiff fingers, purpled at its tips, several calcified deposits in the glutes and hips of hardened consistency. The patient’s case had no improvement despite a variety of Western treatments approaches.  Looking for another point of view on the issue, the patient sought an acupuncture clinic for the treatment of scleroderma.

Results: Three sessions of auricular acupuncture associated with apex ear bloodletting and diet for restoration of the energy balance of Yin, Yang, Qi and Blood were sufficient to have gain improvement with the softening of the skin and the calcifications that the patient presented on the glutes and hips. The patient stated she felt more “rejuvenated, emotionally balanced and cheerful.”

Conclusion: The conclusion of this study is that scleroderma may be linked with energy alterations of Yin,Yang, Qi and Blood and it is possible to make an appropriate treatment rebalancing these energies.

Biography:

Huang Wei Ling, born in Taiwan, raised and graduated in medicine in Brazil, specialist in infectious and parasitic diseases, a General Practitioner and Parenteral and Enteral Medical Nutrition Therapist. Once in charge of the Hospital Infection Control Service of the City of Franca’s General Hospital, she was responsible for the control of all prescribed antimicrobial medication and received an award for the best paper presented at the Brazilian Hospital Infection Control Congress in 1998. Since 1997, she has been presenting her work worldwide, working with the approach and treatment of all diseases of all systems of the human body in a holistic way, with treatment guided through the teachings of Traditional Chinese Medicine and Hippocrates.
 

Abstract:

Introduction: Acne is the occurance inflamed or infected sebaceous glands in the skin. According to Traditional Chinese Medicine, acne is caused by internal Heat retention and invasion of Dampness. 

Purpose: To demonstrate the importance of the correction  of the energy imbalances and chakras energy deficiency on the treatment of acne. 

Methods: Two case reports of one teenager and a young adult, with acne for several years. The first patient did treatment with topical antibiotics and creams, having small improvement with relapses after the withdrawn of the medication. The second patient did two treatments with Isotretinoin, with improvement, but recurrence after the withdrawn of the medication as well.  Both patients were submitted to measurement of the chakras, which revealed complete deficiency on six of the seven chakras, measured in level 1 of 8. Both patients started treatment with auricular acupuncture associated with apex ear bloodletting, Chinese dietary counselling and use of homeopathy to replenish the energy of the chakras. The second patient is performing the same treatment, with the addition of crystal-based medications. 

Results: Both patients had improvement with the treatment instituted and are still being treated, but improvement was noticed three months after the beginning of the treatment, in the case of the first patient, and one month of treatment for the second patient. 

Conclusion: For the treatment of patients with acne it is important to treat the energy imbalances at the root level, reorientating the diet, correcting the energy imbalances and replenishing the chakras energy with high-dilluted medications.      

Biography:

Abstract:

The objective of the Research paper is to identify the treatment of Scabies in homeopathic.  The research Project is experimental and descriptive. The population in the research is the patients of scabies. The researcher selected twenty patients of scabies in Tehsil  Kabal of district Swat as a sample.  The sample was kept under controlled observation. Primary and secondary data was collected about the scabies and its treatment. Different medicines were prescribed to a group of the sample consisting of 10 patients. The second group consisting of 10 patients of the sample was prescribed the mixture of PUMMARIA INDICA and AJUGA BRACTEOSA  Both the groups were interviewed and observed by the researcher. The research finds out that the mixture of PUMMARIA INDICA and AJUGA BRACTEOSA is more effective treatment of scabies than the treatment prescribed by the previous research works.

Biography:

Lydia Gauthier is passionate about cosmetology, the skin and how it interacts with skincare and its external environment. In 8 years, she completed her bachelors in medicinal and bioorganic chemistry, her first master’s degree in pharmaceutical research in tissue engineering as part of a research team focused on psoriasis (LOEX), and a second master’s degree in industrial cosmetology at IPIL in Lyon, France. She therefore achieved her goal of becoming a Dermocosmetologist (Dermopharmacist in France). Following her studies, she worked as a medical representative for La Roche-Posay, as a trusted advisor and trainer to dermatologists, pediatricians, doctors, and nurses. Then, she started her own training company and now works with pharmacists, too, as well as cosmeticians and estheticians.

Abstract:

Canada is the second-largest country in the world, with the most diagnoses of skin cancer, plus 30% of the population suffers from chronic facial erythema, and eczema statistics continue to rise.

 Our biggest challenge: our shortage of dermatologists for the size of our territory and their exodus to aesthetic, rather than traditional practices. We can wait up to a year for a problem of the pathological type, but only two weeks for a Botox injection, for example.

 Pharmacists are not well trained enough in topical galenics and are practically no longer preparing magistral formulae. Cosmeticians have been unable to work in therapeutic complement with their pharmacists and our estheticians (beauticians) are still considerably underestimated.

Which led me to teach chemists about cosmetics to make them want to know more about the skin and cosmetology; train pharmacists in topical galenics; develop a training program for estheticians; and take part in the creation of the first pharmacy training program for cosmeticians, because we urgently need to learn to work as a team, and my role is to build bridges between professions to improve access to dermatological care and treatment. And, as a European formulator, I help companies in creating products that respect the integrity of the skin, while fulfilling their expectations for their efficacy.

Biography:

Al-Asmari A has completed his PhD in 1996 from University of London, London, UK. Earlier he received MPhil (Biochemistry) from London, UK. He is the director of Scientific Research Center, MSD Riyadh, Saudi Arabia. He has over 100 publications that have been cited several times.  He has been serving as an editorial board member of various Journals.

Abstract:

Vitiligo is an acquired, autoimmune skin disorder characterized by melanocyte loss resulting into progressive depigmentation of skin and hair. Vitiligo commonly shows familial aggregation and multifactorial mode of inheritance.  It is a polygenic disease and several genes related to oxidative stress have been associated with the pathogenesis of vitiligo. The present study was aimed to investigate any possible association of inducible nitric oxide synthase (iNOS) gene polymorphisms (iNOS 954 G/C and iNOS Ex16+14 C/T) with vitiligo in Saudis. This study includes 120 vitiligo cases and 120 healthy matched controls. Polymerase chain reaction with restriction fragment length polymorphism method was used for the analysis of genetic polymorphisms. The heterozygous genotype GC and variant allele-C of iNOS-954 G/C were significantly increased in vitiligo patients (p = 0.001), while the frequency of genotype GG was higher in controls. The frequencies of alleles and genotypes of iNOS-Ex16+14 polymorphism did not differ significantly in patient and control groups. However when genotype GC of iNOS-954 was co-inherited with  genotype CT of iNOS-Ex16+14 C/T, the significant association was observed with vitiligo (p = 0.001). Stratification of genotype and allele frequencies of iNOS-954 G/C and iNOS-EX16+14 C/T between male and female yieleded no significant differences. These results indicted that iNOS-954-G/C polymorphism is significantly associated with vitiligo and could be considered as a genetic risk factors for vitiligo susceptibility in Saudis. However, additional studies are warranted using large number of samples from different ethnicity and geographical areas to strengthen this.

Biography:

Huang Wei Ling, born in Taiwan, raised and graduated in medicine in Brazil, specialist in infectious and parasitic diseases, a General Practitioner and Parenteral and Enteral Medical Nutrition Therapist. Once in charge of the Hospital Infection Control Service of the City of Franca’s General Hospital, she was responsible for the control of all prescribed antimicrobial medication and received an award for the best paper presented at the Brazilian Hospital Infection Control Congress in 1998. Since 1997, she has been presenting her work worldwide, working with the approach and treatment of all diseases of all systems of the human body in a holistic way, with treatment guided through the teachings of Traditional Chinese Medicine and Hippocrates.
 

Abstract:

Introduction: Congenital hairy melanocytic nevus (CHMN) is considered a rare congenital disease, which appears in about 1 / 20,000 births. Giant congenital hairy melanocytic nevus (GCHMN) occurs every 50,000 to 500,000 births. CHMN develops during the first trimester of pregnancy, and the etiology remains unknown. The treatment usually occurs with the use of dermabrasion and phenol peeling, which seeks to remove the first layers of the melanocytic nevus, with aesthetic goals. According to Traditional Chinese Medicine, CHMN can be caused by invasion of external pathogens, such as Wind, leading to stagnation of Qi and Blood, blocking the channels and vessels, causing the occurrence of the lesions, or by deficiency of Kidney’s energy.

Purpose: To demonstrate that GCHMN may have clinical treatment and positive responses, avoiding surgical procedures.

Methods: A case report of a 6-month-old male patient diagnosed with GCHMN; different doctors evaluated his condition as untreatable. The surgery was an option, with removal of the affected tissue and transplantation of normal skin tissue, but as the disease was spread all over the body, it was almost impossible. After hearing from another physician with insight into Traditional Chinese and quantum medicine, the patient was treated with acupuncture, received Chinese dietary counselling and quantum medication.

Results: Significant clinical improvement was observed with the treatment, with less pigmentation of the lesions.

Conclusion: There is clinical treatment for GCHMN. For this goal, the physician must have a holistic view of the patient and not focus solely on the injury of the skin itself.

Biography:

Abstract:

Benefits of Placenta:

Stimulates skin cell renewal therapy reinvigorating old cells and generating new healthy cells. The result is an increasingly youthful appearance.

Provides intense hydration to the skin returning firmness suppleness whilst reducing fine and wrinkles.

Reduces pigmentation and diminishes the appearance of spots, blemishes, and discoloration.

Promotes smooth translucent skin complexion.

Increases skin elasticity thereby reducing the appearance of sagging skin. Encourages rapid healing and reducing scars.

Returns vigor to dry, aged skin with replaces it with young and radiant looking skin.

Placenta facials involves stem cells , which are infused into skin with microdermabrasion followed by ionization of the placenta extract in the. Skin along with facial therapy , placenta is full

Nutrients, minerals, amino acids, and proteins, the nutritional extract heal skin aging. Placenta extract can be. Used with electroporation for face , topical daily creams and serum with derma roller for face and hair.

Why placenta is the hottest beauty ingredients in the world now? Because it is safe and natural.

Afrah Beauty Line established 2018 based in Russia and Kuwait, specializing in skin care and also corsets for body.

Our product are manufactured in Japan

We have more than 16 products of skin care

All the products are licensed by the Kuwait Ministry of Health

Biography:

Abstract:

Benefits of Placenta:

Stimulates skin cell renewal therapy reinvigorating old cells and generating new healthy cells. The result is an increasingly youthful appearance.

Provides intense hydration to the skin returning firmness suppleness whilst reducing fine and wrinkles.

Reduces pigmentation and diminishes the appearance of spots, blemishes, and discoloration.

Promotes smooth translucent skin complexion.

Increases skin elasticity thereby reducing the appearance of sagging skin. Encourages rapid healing and reducing scars.

Returns vigor to dry, aged skin with replaces it with young and radiant looking skin.

Placenta facials involves stem cells , which are infused into skin with microdermabrasion followed by ionization of the placenta extract in the. Skin along with facial therapy , placenta is full

Nutrients, minerals, amino acids, and proteins, the nutritional extract heal skin aging. Placenta extract can be. Used with electroporation for face , topical daily creams and serum with derma roller for face and hair.

Why placenta is the hottest beauty ingredients in the world now? Because it is safe and natural.

Afrah Beauty Line established 2018 based in Russia and Kuwait, specializing in skin care and also corsets for body.

Our product are manufactured in Japan

We have more than 16 products of skin care

All the products are licensed by the Kuwait Ministry of Health

Biography:

Author has completed his MBBS , MRCS . He is basic surgical trainee at Newcastle upon Tyne hospitals, UK. He has published more than 20 papers in reputed journals

Abstract:

INTRODUCTION:

Skin biopsy is an established diagnostic procedure that aids dermatologists in overcoming the diagnostic predicament, which occurs during consultation. The management of skin diseases requires concrete diagnosis, which constitutes an intricate process, in many occasions.

MATERIAL AND METHODS:

The purpose of this study is to define the correlation between clinical and histopathological diagnoses of LICHEN PLANUS in the cases which were registered at Essa laboratory and diagnostics, Karachi from January 2013 to December 2015.

RESULTS:

We analyze 880 patients of which 54 patients were clinically diagnosed with lichen planus, there were 31 (57.4%) of male and 23 (42.6%) female. In this study, 33 (61.1%) patient where correctly diagnosed to be lichen planus or lichenoid like lesion on biopsy, whereas 21 (38.9%) were mis-diagnosed as epithelial hyperplasia and chronic dermatitis. By applying t-test between clinical diagnosis and histopathological, p value is found to be 0.03.

CONCLUSION:

These results verified the aforementioned hypothesis that the patients who are diagnosed with lichen planus lesion must undergo biopsy for the confirmation of the disease.

Biography:

Abstract:

Clinical Finding:

A 63 years old female presented to clinic with 6 years history of discoloured areas on right palm, right middle and ring fingers. This has been asymptomatic except for one episode of bleeding following minor trauma. Examination revealed dull red, flat, non-pulsatile areas on palm. There was no hyperkeratosis or ulceration.

Investigations:

Skin biopsy was performed with the following findings: Epidermis: thick keratin. Dermis: oesinophilic material, probably fibrin with loose strauma and loose red cells, some ectasia of small blood vessels but no hemosiderin.

Diagnosis: Cutaneous Amyloidosis

Discussion:

Amyloidosis is explained by extra cellular deposition of proteinaceous substance or various insoluble proteins that results in considerable tissue dysfunction. It may affect several body organs. Amyloidosis is usually classified as primary or secondary according to underlying cause. In this case clinical findings suggested Primary Localised Cutaneous Amyloidosis (PLCA); that is deposition of amyloid in previously normal skin with no evidence of deposits in internal organs. PLCA is classified to Macular, Papular or lichen amyloidosis, Nodular or tumefactive and Familial. This case suggests Macular form of PLCA although it differs from some usual clinical and pathological presentations.

Primary cutaneous amyloidosis has been reported in different body areas. Familial PLCA shows autosomal dominant inheritance. Management of PLCA is challenging. In this case, patient was treated with potent topical steroid with no significant improvement. Other options include: Calcipotriol, Phototherapy, DMSO (dimethyl sulfoxide), Etretinate, Acitretin, Cyclophosphamide, Ciclosporin, Cryotherapy, Dermabrasion, CO2 laser and surgical measures.

Biography:

Abstract:

Actinic keratosis (AK), a hyperkeratotic lesion induced by solar exposure, is the precancerous lesion that most frequently develops into squamous cell carcinoma. In recent years, Photodynamic Therapy (PDT), has asserted itself as a new effective and safe method for the treatment of actinic keratoses with almost no side effects. The aim of this study is to verify whether a third treatment may now be added to the “Conventional-PDT" and “Daylight-PDT": PhotoDynamic Therapy activated by Intense Pulsed Light  (IPL-PDT).

31 patients, 24 males and 7 females, in most cases elderly, were included in the trial. As in the previous methods, also in IPL-PDT, 5-methylaminolevulinic acid (MAL) was applied topically for a period of 3 hours. Thereafter, the occlusive dressing and the topical cream, were removed and the neoformation was irradiated with IPL, with a 640nm filter with variable power. Irradiation was performed in single or multiple sessions, depending on the type of keratosis, to completely cover the lesion and the apparently healthy surrounding areas, i.e. the cancerization field.

Results were evaluated 3, 6 and 9 months after treatment. Treatment achieved a 95% complete clearance rate, with a 5% partial relapse 9 months after the last treatment.

The above method is a valid alternative to methods already in use. The results obtained demonstrate the efficacy and tolerability of the treatment described which, due to its versatility and speed of use, is preferable to the methods used so far.

Biography:

Selamawit Worku Asmare is a second year dermatovenereology resident at Addis Ababa University School of Medicine, Ethiopia. She received her medical degree in 2014 from Addis Ababa University School of Medicine, after which she served in the rural part of the country for 2 years. From January, 2017 to January 2018 she worked as a General practitioner and Lecturer at Yekatit 12 Hospital Medical Collage. Selamawit wants to work on improving the dermatology service in her country especially in the rural parts where there is scarcity of medical care.

Abstract:

Scabies is Skin infestation caused by the penetration of the obligate human parasitic mite Sarcoptes scabiei var. hominis into the epidermis. Crusted scabies is rare and severely debilitating form of presentation. It accounts for <0.5% cases of erythroderma. The rarity of this presentation makes crusted scabies a diagnostic challenge.

A 34 years old male patient presented with Skin rash of 3 months duration. He is a known RVI patient for the past 5 years on HAART with CD4 count of 145. The rash initially started from finger web and progressively worsened to involve trunk, abdomen, extremities, and genitalia. It is associated with mild and occasional itching. On integumentary system there was Hyperkeratotic crusted plaque with fissuring over trunk, abdomen, and bilateral upper and lower extremity with significant underlying erythema involving > 90% BSA. There was involvement of palm and sole. He was being treated for Atopic Dermatitis with topical steroid at different clinics. Investigated with Complete blood count, renal function test, liver function test, serum electrolytes, albumin and all within normal range. Skin scrapping examined under microscope revealed scabies mite.  With this he was diagnosed with Erythroderma secondary to crusted scabies. He was treated with oral  ivermectin 200mcg/kg/dose given on day 1,2,8,9 and 15 and 25% benzoyl benzoate applied daily for 7 days, then twice weekly for 5 weeks and keratolytic.  He had significant improvement after 5 weeks of treatment.

This case indicates that crusted scabies is associated with HIV infection and that it can result in erythroderma.  And since typical symptoms of scabies are usually absent, high index of suspicion is necessary to reach to diagnosis.

Biography:

Huraib GB has completed his PhD in Dermatological and Venereal Diseases from Fribourge  University, Germany. Earlier he did MBBS from Faculty of Medicine / King Saud University, Riyadh. He  is the Deputy Director of Medical Srvices Department (MSD) for armed forces, Saudi Arabia. He has published several papers on genrtic basis of dermatological disesaes.

Abstract:

Atopic dermatitis (AD), also known as atopic eczema, is a chronic inflammatory skin disease characterized by severe itching and recurrent, relapsing eczema-like skin lesions, affecting up to 15% of children in industrialized countries. AD is a complex multifactorial disease, and its exact etiology and pathogenesis have not been fully elucidated. The aim of this study was to investigate the impact of gene polymorphisms of T helper cell subtype Th1 cytokine, interferon-gamma (IFN-γ) on AD susceptibility in a Saudi cohort.  Hundred four unrelated patients with AD and 195 healthy controls were genotyped for IFN-γ (874A/T) polymorphism. Genomic DNA was extracted from the peripheral blood of AD patients and controls using QIAamp^R DNA mini kit. IFN-γ gene was amplified using amplification refractory mutation systems (ARMS)-PCR methodology to detect polymorphisms at position 874 of IFN-γ. The frequency of genotype AT of IFN-γ (874A/T) was significantly higher while genotype AA was lower in AD patients as compared to controls (P <0.001). The frequency of T containing genotypes (AT+TT) was also higher in AD patients as compared to that in controls (P = 0.001). The frequencies of allele T and A were statistically different in patients and controls (P = 0.04). These results indicated that genotype AT of IFN-γ (874A/T) polymorphism is associated with AD risk and genotype AA is protective to AD. It is concluded that IFN-γ (874A/T) polymorphism is associated with the susceptibility of AD, however further studies with large sample size involving different ethnic populations should be conducted to strengthen these results.