Day 1 :
- Plenary Tracks
Location: Room Cassiopee
Newcastle upon Tyne Hospitals, UK
Title: Clinical and histopathological correlation of lichen and lecheniod lesions
Time : 10:15-10:45
Ahmad Faraz has completed his MBBS, MRCS. He is basic Surgical Trainee at Newcastle upon Tyne hospitals, UK. He has published more than 20 papers in reputed journals.
Introduction: Skin biopsy is an established diagnostic procedure that aids dermatologists in overcoming the diagnostic predicament, which occurs during consultation. The management of skin diseases requires concrete diagnosis, which constitutes an intricate process, in many occasions.
Aims & Methods: The purpose of this study is to define the correlation between clinical and histopathological diagnoses of lichen planus in the cases which were registered at Essa laboratory and diagnostics, Karachi from January 2013 to December 2015.
Results: We analyzed 880 patients of which 54 patients were clinically diagnosed with lichen planus, there were 31 male patients (57.4%) and 23 (42.6%) females. In this study, 33 (61.1%) patients where correctly diagnosed to be lichen planus or lichenoid like lesion on biopsy, whereas 21 (38.9%) were mis-diagnosed as epithelial hyperplasia and chronic dermatitis. By applying t-test between clinical diagnosis and histopathological, p value is found to be 0.03.
Conclusion: These results verified the aforementioned hypothesis that the patients who are diagnosed with lichen planus lesion must undergo biopsy for the confirmation of the disease.
Emily N C Ryder
Middlemore Hospital, New Zealand
Title: Perineuriomatous melanocytic naevi
Time : 10:45-11:15
Perineuriomatous melanocytic naevi are acquired melanocytic naevi with dual melanocytic and perineural differentiation. These tumours may resemble neurofibromas, sclerozing naevi or even desmoplastic melanomas but are distinguished by their lack of cytological atypia and positive staining for EMA and Melan A. Melanocyte and peripheral nerve sheath tumors respectively are usually regarded as distinct tumor types, although both cell lineages originate from the pleuripotent embryological neural crest and both commonly express SOX10 and S100. We had reviewed the literature and present a possibly unique case with multiple such perineuriomatous melanocytic naevi. A 64-year-old Caucasian man presented with dozens of asymptomatic soft papules scattered on his proximal thighs and trunk with subtle foci of pigmentation. Histopathologically each excised lesion was a well-circumscribed compound melanocytic tumour with superficial aspects resembling a common naevus. Melanocytes in the reticular dermis merged with populations of spindled cells in parallel bundles and whorls, within a collagenous stroma with pericellular cracking/clefting. There was no cytological atypia or mitotic activity. Immunohistochemistry demonstrated Melan-A positive superficial melanocytes, whilst the spindle cells were positive for EMA but lacked SOX-10 or Melan-A. Interphase FISH using the Human Centromeric Probe for chromosomes 13/21, subtelomeric probes for 13q, 21q, and 22q, did not identify an abnormality on examination of 100 cells. This possibly unique presentation provides support for the hypothesis that a germline mutation may be responsible for the pathogenesis of these lesions. We suggest this has implications for pathogenesis of this tumorhybrid phenomenon. Further genetic studies may help shed light further on this phenomenon.
University of Toronto Medical School, Canada
Title: Novel psoriasis therapeutics: Examining the anti-inflammatory utility of anti-anxiolytic medications
Statement of the Problem: Psoriasis is a debilitating autoimmune disease defined by erythematous, pruritic, and scaly plaques. Yet, this disease also has numerous extracutaneous associations including depression, heart disease, arthritis, and inflammatory bowel disease. The combination of physical and mental manifestations of psoriasis can be explained, respectively, by inflammatory cytokines that act on skin cells to create scaly patches and brain cells to alter one’s mental state.
Aim: The purpose of this study is to discuss the novel use of anti-anxiolytic medications to address psoriasis therapeutics. Methodology & Theoretical Orientation: To obtain these results, various search terms such as psoriasis and anti-anxiolytics were utilized. Furthermore, the articles were selected based on recency of publication as well as depth of detail regarding the specific immunologic mechanisms by which anti-psychotics exert their therapeutic effects.
Findings: The results show that reducing anxiety can reduce the release of stress compounds, thus reducing body’s inflammatory reaction. Specifically, stress signals such as CRH and substance P contribute to the release of inflammatory cytokines such as TNF-α and interleukins.
Conclusion & Significance: Psoriasis provides evidence for the connection between the psychiatric symptoms caused by changes in the brain and cutaneous symptoms caused by changes in the skin. The bidirectionality of these interactions is used to create a novel use for antianxiolytic medications in treating psoriatic symptoms.
Warkaa Mahmood Ali Al-Wattar
Mustansiriyia University, Iraq
Title: Effect of 790-805 nm diode laser therapy on mast cell in cutaneous wound healing in mice
Warkaa Mahmood Ali Al-Wattar has received her PhD in Oral Histology in 2013. She is the Head of Oral Pathology Department from 2016-2017, Member in IDA, and Editorial Board Member in five Medical and Dental Journals. She has one published book, 14 research papers, editorials and review about 12 research papers in Dentistry. She is responsible for Oral Pathology lab in Mustansiriyah University.
Background & Objective: The use of low level laser therapy (LLLT) has been increased now-a-days to accelerate healing of soft tissue injuries because of some biostimulatory effects. The goal of this study was to investigate the effect of 790-805 nm diode lasers on the inflammatory effect of mast cells during wound healing in rodents.
Materials & Methods: A cut wound (1.5 cm) was done on the cheek of 40 albino mice. Twenty of them exposed to LLLT (360 J/cm2) at 790-805 nm immediately post wounding procedure. The animals were scarified and the wound area was prepared and stained with toluidine blue.
Results: Mean mast cell count of 10.2 on the first day of control group while in laser group 8.4. The control and laser group showed a gradual inclination in the mean value to be return to increase at the day 14 of the experiment. There was a significant difference (P<0.05) in the control group on the first day, while significant difference (P≤0.05) was on the day seven. Pearson correlation showed a significant correlation (P≤0.01) between the control group on the day one and the laser group on the day seven. While there was a significant correlation (P≤0.05) between the control group on the day 14 and laser group on the day one.
Conclusions: LLLT may induce an anti-inflammatory effect on wound healing process by its inhibitory action on mast cells; while it may have a biostimulatory effect on the proliferation of mast cells in the proliferative phase of wound healing which indirectly affects fibrous tissue regeneration in the subcutaneous area.
- Poster Presentations
Location: Room Cassiopee
Rama Malek Okdeh
Tishreen University, Syria
Title: Comparison between the efficacies of platelet rich plasma combined with fractional CO2 laser vs. laser alone in the treatment of facial atrophic acne scar
Rama Malek Okdeh is a Resident Dermatologist in her last year of residency, has graduated from Medicine College with very good rate. Currently, she is preparing to pass the Arabian Dermatology Board Exam and the European Board Exam as well. She has participated in many conferences as Presenter as well as attendee; and found her passion in Dermatology Science and practice. Beside her academic study, she has interest in recording audio books, as Journalist and in classic music.
Introduction: Treating acne scars is a big challenge, many treatments are available but optimized treatment still does not satisfactory with the absence of a multimodal combination approach. While fractional CO2 lasers (FCLs) are an established treatment option, the role of platelet-rich plasma (PRP) in the treatment of acne scars is not established though it is being used extensively in other fields of medicine owing to its healing properties.
Aim: The aim of this study is to evaluate the safety and efficacy of autologous platelet rich plasma combined with fractional CO2 laser for treatment of acne scars. Exclusion Criteria: Exclusion criteria includes history of keloidal scar, active inflammation or infection, oral isotretinoin use within the preceding three months, diabetes mellitus, collagen vascular disease, pregnancy and lactation. Method: Patients underwent split-face therapy, had received ablative fractional carbon dioxide (CO2) laser (10600 nm) (Smartxide DOT, advanced CO2 fractional technology Deka, Florence, Italy) combined with autologous platelet-rich plasma (PRP) treatment on one half of their face and ablative fractional CO2 laser alone on the other half (for comparison). The injection of PRP was administered immediately after laser therapy. Each patient will receive three treatment sessions with one month gap, and will follow up for three months.
Findings: Patients were evaluated in each session and three months after the last sessions to assess the response by using standardized high-resolution digital photographs using identical camera settings, patient positioning, and lighting conditions.
Conclusion: Grading of post-acne scars severity will be performed using the Quantitative Global Grading system of Goodman and Baroon. This will be performed through the assessment of two independent blinded physicians. The physicians will not participate in the study and would not know the treatment protocol
Afrah Beauty Line, Kuwait
Title: In Afrah Beauty Line we bring advances in preventative beauty bath to optimized young white fresh skin
Afrah Abdullah established Afrah Beauty Line based in Russia and Kuwait in 2018, specializing in Skin Care and also corsets for body. Our products are manufactured in Japan, we have more than 16 products of Skin Care, and all the products are licensed by the Kuwait Ministry of Health.
Stimulate skin cell renewal therapy reinvigorating old cells and generating new healthy cells. The result is an increasingly youthful appearance. Provides intense hydration to the skin returning firmness suppleness whilst reducing fine and wrinkles reduces pigmentation and diminishes the appearance of spots, blemishes, and discoloration promotes smooth translucent skin complexion. Increases skin elasticity thereby reducing the appearance of sagging skin. Encourages rapid healing and reducing scars; returns vigor to dry, aged skin with replaces it with young and radiant looking skin. Placenta facials involves stem cells, which are infused into skin with microdermabrasion followed by ionization of the placenta extract in the. Skin along with facial therapy, placenta is full nutrients, minerals, amino acids, and proteins, the nutritional extract heal skin aging. Placenta extract can be used with electroporation for face, topical daily creams and serum with derma roller for face and hair. Why placenta is the hottest beauty ingredients in the world now? Because it is safe and natural.